Why is Perl used so extensively in biology research?
I work as support staff in a biology research institute as a student, and Perl seems to be used everywhere. Not for every single project, but it seems that more than half the people here have a few Perl books in/on their office/desk.
Why is Perl used so much in biology?
Answer
Lincoln Stein highlighted some of the saving graces of Perl for bioinformatics in his article: How Perl Saved the Human Genome Project.
From his analysis:
I think several factors are responsible:
Perl is remarkably good for slicing, dicing, twisting, wringing, smoothing, summarizing and otherwise mangling text. Although the biological sciences do involve a good deal of numeric analysis now, most of the primary data is still text: clone names, annotations, comments, bibliographic references. Even DNA sequences are textlike. Interconverting incompatible data formats is a matter of text mangling combined with some creative guesswork. Perl's powerful regular expression matching and string manipulation operators simplify this job in a way that isn't equalled by any other modern language.
Perl is forgiving. Biological data is often incomplete, fields can be missing, or a field that is expected to be present once occurs several times (because, for example, an experiment was run in duplicate), or the data was entered by hand and doesn't quite fit the expected format. Perl doesn't particularly mind if a value is empty or contains odd characters. Regular expressions can be written to pick up and correct a variety of common errors in data entry. Of course this flexibility can be also be a curse. I talk more about the problems with Perl below.
Perl is component-oriented. Perl encourages people to write their software in small modules, either using Perl library modules or with the classic Unix tool-oriented approach. External programs can easily be incorporated into a Perl script using a pipe, system call or socket. The dynamic loader introduced with Perl5 allows people to extend the Perl language with C routines or to make entire compiled libraries available for the Perl interpreter. An effort is currently under way to gather all the world's collected wisdom about biological data into a set of modules called "bioPerl" (discussed at length in an article to be published later in the Perl Journal).
Perl is easy to write and fast to develop in. The interpreter doesn't require you to declare all your function prototypes and data types in advance, new variables spring into existence as needed, calls to undefined functions only cause an error when the function is needed. The debugger works well with Emacs and allows a comfortable interactive style of development.
Perl is a good prototyping language. Because Perl is quick and dirty, it often makes sense to prototype new algorithms in Perl before moving them to a fast compiled language. Sometimes it turns out that Perl is fast enough so that of the algorithm doesn't have to be ported; more frequently one can write a small core of the algorithm in C, compile it as a dynamically loaded module or external executable, and leave the rest of the application in Perl (for an example of a complex genome mapping application implemented in this way, see http://waldo.wi.mit.edu/ftp/distribution/software/rhmapper/).
Perl is a good language for Web CGI scripting, and is growing in importance as more labs turn to the Web for publishing their data.