My application running on a Windows server makes use of a Jet/Access database. For some reasons around every two weeks that database file gets locked by the System process (PID 4, seems to be fixed)
After some googling I found some other users having their files locked by that special process, but different files (of course).
Files accessed through a share will be locked by the system process (PID 4).
Try opening compmgmt.msc
-> System Tools -> Shared Folders -> Open Files to see if the locked file is listed there
See also the sysinternals forum for a way to replicate this.
Not all applications lock files when they are opened, Excel however does. I don't know if Access does the same...