I'm having issue on Visual Studio Pro 2015 when trying to debug (ARM Solution Platform selected) on a Windows 10 Mobile physical device on my desktop.
The physical device: Nokia Lumia 920 OS Build 10.0.10586.36 (Developer mode) (device not in lock screen and is powered on)
My Desktop: Windows 10 Pro, Intel Core i5-4670K 8GB RAM 64-bit OS Build 10.0.10586.36 (Developer mode)
I do not have this issue on my laptop using the same Nokia Lumia 920.
Severity Code Description Project File Line Suppression State Error Error : DEP6100 : The following unexpected error occurred during bootstrapping stage 'Connecting to the device '30F105C9-681E-420b-A277-7C086EAD8A4E'.': DeviceException - Deployment failed because no Windows Phone was detected. Make sure a phone is connected and powered on. App1
Error Error : DEP6200 : Bootstrapping 'Device' failed. Device cannot be found. Deployment failed because no Windows Phone was detected. Make sure a phone is connected and powered on. App1
So far I've tried restarting both devices and re-installing Visual Studio 2015.
EDIT: So after I've tried the proposed solution, this is what I got even for my emulator. Tried re-installing and repairing, nothing works.
Severity Code Description Project File Line Suppression State Error Error : DEP6100 : The following unexpected error occurred during bootstrapping stage 'Connecting to the device '8BDF218D-FDBB-4A97-90F9-3AA33B559A92'.': DeviceException - The system cannot find the file specified. App1
Error Error : DEP6200 : Bootstrapping 'Mobile Emulator 10.0.10240.0 WVGA 4 inch 512MB' failed. Device cannot be found. The system cannot find the file specified. App1
I was able to solve the emulator issue by Installing a newer version of Microsoft Emulator for Windows 10 mobile from https://dev.windows.com/en-us/downloads/sdk-archive.
Next I'll try deleting the driver from device manager and if that fails, I'll restoring my device to factory defaults, enable developer mode, and try again to deploy on a physical device.
EDIT: As for the device issue, I deleted the drivers from Device Manager and now I'm able to deploy my apps onto the physical device.