There are a plethora of questions where people talk about common tricks, notably "Vim+ctags tips and tricks".
However, I don't refer to commonly used shortcuts that someone new to Vim would find cool. I am talking about a seasoned Unix user (be they a developer, administrator, both, etc.), who thinks they know something 99% of us never heard or dreamed about. Something that not only makes their work easier, but also is COOL and hackish. After all, Vim resides in the most dark-corner-rich OS in the world, thus it should have intricacies that only a few privileged know about and want to share with us.
Might not be one that 99% of Vim users don't know about, but it's something I use daily and that any Linux+Vim poweruser must know.
Basic command, yet extremely useful.
:w !sudo tee %
I often forget to sudo before editing a file I don't have write permissions on. When I come to save that file and get a permission error, I just issue that vim command in order to save the file without the need to save it to a temp file and then copy it back again.
You obviously have to be on a system with sudo installed and have sudo rights.