By "handle" I mean manipulate multi-columnar rows of data. How does R stack up against tools like Excel, SPSS, SAS, and others? Is R a viable tool for looking at "BIG DATA" (hundreds of millions to billions of rows)? If not, which statistical programming tools are best suited for analysis large data sets?
If you look at the High-Performance Computing Task View on CRAN, you will get a good idea of what R can do in a sense of high performance.