I've been learning python for a while now with some success. I even managed to create one or two (simple) programs using PyGtk + Glade.
The thing is: I am not sure if the best way to use GTK with python is by building the interfaces using Glade.
I was wondering if the more experienced ones among us (remember, I'm just a beginner) could point out the benefits and caveats of using Glade as opposed to creating everything in the code itself (assuming that learning the correct gtk bindings wouldn't exactly be a problem).
I would say that it depends: if you find that using Glade you can build the apps you want or need to make than that's absolutely fine. If however you actually want to learn how GTK works or you have some non-standard UI requirements you will have to dig into GTK internals (which are not that complicated).
Personally I'm usually about 5 minutes into a rich client when I need some feature or customization that is simply impossible through a designer such as Glade or Stetic. Perhaps it's just me. Nevertheless it is still useful for me to bootstrap window design using a graphical tool.
My recommendation: if making rich clients using GTK is going to be a significant part of your job/hobby then learn GTK as well since you will need to write that code someday.
P.S. I personally find Stetic to be superior to Glade for design work, if a little bit more unstable.