I've just tried installing MySQL using homebrew (on Mac OS X 10.6), but I've run across an issue at the first hurdle. When trying to manually start the server (mysql.server start), I get the following error:
. ERROR! Manager of pid-file quit without updating file.
Unfortunately I'm not sure of which error logs or configuration files to check, as I've never installed MySQL in this way before.
I ran into this same problem when installing via homebrew. Make sure you run these commands (which are listed during install but easy to miss):
unset TMPDIR
mysql_install_db