A response on SO got me thinking, does JavaScript guarantee a certain endian encoding across OSs and browsers?
Or put another way are bitwise shifts on integers "safe" in JavaScript?
Shifting is safe, but your question is flawed because endianness doesn't affect bit-shift operations anyway. Shifting left is the same on big-endian and little-endian systems in all languages. (Shifting right can differ, but only due to interpretation of the sign bit, not the relative positions of any bits.)
Endianness only comes into play when you have the option of interpreting some block of memory as bytes or as larger integer values. In general, Javascript doesn't give you that option since you don't get access to arbitrary blocks of memory, especially not the blocks of memory occupied by variables. Typed arrays offer views of data in an endian-sensitive way, but the ordering depends on the host system; it's not necessarily the same for all possible Javascript host environments.
Endianness describes physical storage order, not logical storage order. Logically, the rightmost bit is always the least significant bit. Whether that bit's byte is the one that resides at the lowest memory address is a completely separate issue, and it only matters when your language exposes such a concept as "lowest memory address," which Javascript does not. Typed arrays do, but then only within the context of typed arrays; they still don't offer access to the storage of arbitrary data.