I've got this error and tried some solutions I found here but they didn't work.
I don't know why and how to solve this. Please help.
Android Studio 2.1.2
07-12 18:28:46.742 642-642/com.vuforia.samples.VuforiaSamples E/AndroidRuntime: FATAL EXCEPTION: main
Process: com.vuforia.samples.VuforiaSamples, PID: 642
java.lang.RuntimeException: Unable to instantiate application com.android.tools.fd.runtime.BootstrapApplication: java.lang.ClassNotFoundException: Didn't find class "com.android.tools.fd.runtime.BootstrapApplication" on path: DexPathList[[zip file "/data/app/com.vuforia.samples.VuforiaSamples-2/base.apk"],nativeLibraryDirectories=[/data/app/com.vuforia.samples.VuforiaSamples-2/lib/arm, /data/app/com.vuforia.samples.VuforiaSamples-2/base.apk!/lib/armeabi-v7a, /vendor/lib, /system/lib]]
at android.app.LoadedApk.makeApplication(LoadedApk.java:676)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:6294)
at android.app.ActivityThread.access$1800(ActivityThread.java:222)
at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1861)
at android.os.Handler.dispatchMessage(Handler.java:102)
at android.os.Looper.loop(Looper.java:158)
at android.app.ActivityThread.main(ActivityThread.java:7229)
at java.lang.reflect.Method.invoke(Native Method)
at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:1230)
at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:1120)
Caused by: java.lang.ClassNotFoundException: Didn't find class "com.android.tools.fd.runtime.BootstrapApplication" on path: DexPathList[[zip file "/data/app/com.vuforia.samples.VuforiaSamples-2/base.apk"],nativeLibraryDirectories=[/data/app/com.vuforia.samples.VuforiaSamples-2/lib/arm, /data/app/com.vuforia.samples.VuforiaSamples-2/base.apk!/lib/armeabi-v7a, /vendor/lib, /system/lib]]
at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
at android.app.Instrumentation.newApplication(Instrumentation.java:1004)
at android.app.LoadedApk.makeApplication(LoadedApk.java:666)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:6294) at android.app.ActivityThread.access$1800(ActivityThread.java:222)
at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1861)
at android.os.Handler.dispatchMessage(Handler.java:102)
at android.os.Looper.loop(Looper.java:158)
at android.app.ActivityThread.main(ActivityThread.java:7229)
at java.lang.reflect.Method.invoke(Native Method)
at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:1230)
at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:1120)
Suppressed: java.lang.ClassNotFoundException: com.android.tools.fd.runtime.BootstrapApplication
at java.lang.Class.classForName(Native Method)
at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
... 12 more
Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack trace available
After a few search i came up this sollution, Its because of the android studio tries to instant run. to turn off this feature
setting Secreenshot for reference. Thanks hopefully it may help you.