I'm not totally sure what the difference is between setting dex option "jumbomode" to true vs adding multidex support.
Setting jumbo mode to true or multidex to true seems to fix the problem below
AGPBI: {"kind":"SIMPLE","text":"UNEXPECTED TOP-LEVEL EXCEPTION:","position":{},"original":"UNEXPECTED TOP-LEVEL EXCEPTION:"}
AGPBI: {"kind":"SIMPLE","text":"com.android.dex.DexIndexOverflowException: Cannot merge new index 65772 into a non-jumbo instruction!","position":{},"original":"com.android.dex.DexIndexOverflowException: Cannot merge new index 65772 into a non-jumbo instruction!"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer.jumboCheck(InstructionTransformer.java:109)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer.jumboCheck(InstructionTransformer.java:109)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer.access$800(InstructionTransformer.java:26)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer.access$800(InstructionTransformer.java:26)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer$StringVisitor.visit(InstructionTransformer.java:72)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer$StringVisitor.visit(InstructionTransformer.java:72)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.io.CodeReader.callVisit(CodeReader.java:114)","position":{},"original":"\tat com.android.dx.io.CodeReader.callVisit(CodeReader.java:114)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.io.CodeReader.visitAll(CodeReader.java:89)","position":{},"original":"\tat com.android.dx.io.CodeReader.visitAll(CodeReader.java:89)"}
AGPBI: {"kind":"SIMPLE","text":"\tat com.android.dx.merge.InstructionTransformer.transform(InstructionTransformer.java:49)","position":{},"original":"\tat com.android.dx.merge.InstructionTransformer.transform(InstructionTransformer.java:49)"}
...
Jumbo Mode, when reading https://source.android.com/devices/tech/dalvik/dalvik-bytecode.html, the const-string/jumbo is the jumbo mode for string. It is about the opcode such that "op vAA, string@BBBBBBBB" versus "op vAA, string@BBBB", 32 bits versus 16 bit.
Multi Dex is to allow to load classes from more than one dex file. The primary classes.dex must contain the classes necessary for calling this class methods. Secondary dex files found in the application apk will be added to the classloader after first call to MultiDex.install(Context) see https://developer.android.com/reference/android/support/multidex/MultiDex.html