I'm using irssi in one pane and nicklist.pl in the other, and whenever I'm in the irssi pane, the nicklist pane is dimmed:
How do I stop the inactive pane from dimming?
Found it! There is a setting in Settings -> Appearance -> Dim inactive split panes. I would have quite liked to be able to set it for just the two profiles, but it doesn't matter that much.