How do I change the default coloring/fonts in Dreamweaver CS5?
Answer
Code color: Edit (Dreamweaver on Mac) -> Preferences, Code Color category, select that document type you want to edit and then click the Edit Coloring Scheme button. Color away.
Since you give no clue as to what you'd actually like to see in your question, if you happen to like a "dark" theme, then check out the instructions on the following page: http://www.sramekdesign.com/dreamweaver/dark-coding-colorization-for-dreamweaver/
Fonts: Edit (Dreamweaver on Mac) -> Preferences, Fonts category. You should be able to choose from any font that is installed on your system. For font recommendations see: Recommended Fonts for Programming?