Is there a way to do a query and exclude a list of things, instead of calling exclude multiple times?
Based on your reply to Ned, it sounds like you just want to exclude a list of tags. So you could just use the in
filter:
names_to_exclude = [o.name for o in objects_to_exclude]
Foo.objects.exclude(name__in=names_to_exclude)
Does that do what you want?