I want to create a website and I am confused which web framework to use. Please recommend me which framework is better: Django or Zope. I am using Python.
If you mean plain Zope2 by zope then I'd go for Django. Most interesting stuff in the Zope world takes place with either Plone or Grok (which is Zope3, which is actually quite different from Zope2).
Grok works nice with relational databases, Plone doesn't really, so if you depend on an RDBMS, either go with Grok or Django.
Zope and Plone have a rather steep learning curve so you'll get started more quickly with Django.
The largest downside about Django is, in my opinion, that it tries do do everything by itself (templating, object publishing, ORM, and so on) while there are many excellent existing components out there. If you want to be able to use your code / knowledge outside of the web framework you're using, consider Pylons or BFG
Many options, no clear answer, sorry :)