What is the difference between GTK# and windows forms? Are they totally different?
Thanks
Gtk#:
GTK# is a .NET binding for the Gtk+ toolkit. The toolkit is written in C for speed and compatibility, while the GTK# binding provides an easy to use, object oriented API for managed use. It is in active development by the Mono project, and there are various real-world applications available that use it (Banshee , F-Spot, Beagle, MonoDevelop).
In general, GTK# applications are written using MonoDevelop, which provides a visual designer for creating GTK# GUIs.
Platforms: Unix, Windows, OSX
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Windows.Forms is a binding developed by Microsoft to the Win32 toolkit. As a popular toolkit used by millions of Windows developers (especially for internal enterprise applications), the Mono project decided to produce a compatible implementation (Winforms) to allow these developers to easily port their applications to run on Linux and other Mono platforms.
Whereas the .Net implementation is a binding to the Win32 toolkit, the Mono implementation is written in C# to allow it to work on multiple platforms. Most of the Windows.Forms API will work on Mono, however some applications (and especially third party controls) occasionally bypass the API and P/Invoke straight to the Win32 API. These calls will likely have to changed to work on Mono.
In general, Winforms applications are written using Microsoft's Visual Studio or SharpDevelop, which both provide a visual designer for creating Winforms GUIs.
Platforms: Windows, Unix, OSX
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Source: Picking the Right Toolkit