When is it acceptable to call GC.Collect?
The general advise is that you should not call GC.Collect from your code, but what are the exceptions to this rule?
I can only think of a few very specific cases where it may make sense to force a garbage collection.
One example that springs to mind is a service, that wakes up at intervals, performs some task, and then sleeps for a long time. In this case, it may be a good idea to force a collect to prevent the soon-to-be-idle process from holding on to more memory than needed.
Are there any other cases where it is acceptable to call GC.Collect?
Answer
If you have good reason to believe that a significant set of objects - particularly those you suspect to be in generations 1 and 2 - are now eligible for garbage collection, and that now would be an appropriate time to collect in terms of the small performance hit.
A good example of this is if you've just closed a large form. You know that all the UI controls can now be garbage collected, and a very short pause as the form is closed probably won't be noticeable to the user.
UPDATE 2.7.2018
As of .NET 4.5 - there is GCLatencyMode.LowLatency and GCLatencyMode.SustainedLowLatency. When entering and leaving either of these modes, it is recommended that you force a full GC with GC.Collect(2, GCCollectionMode.Forced).
As of .NET 4.6 - there is the GC.TryStartNoGCRegion method (used to set the read-only value GCLatencyMode.NoGCRegion). This can itself, perform a full blocking garbage collection in an attempt to free enough memory, but given we are disallowing GC for a period, I would argue it is also a good idea to perform full GC before and after.
Source: Microsoft engineer Ben Watson's: Writing High-Performance .NET Code, 2nd Ed. 2018.
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